Prognostic significance of PD-L1 expression and tumor infiltrating lymphocyte in surgically resectable non-small cell lung cancer
| Autor: | Dan Hu, Chao Li, Haipeng Xu, Kan Jiang, Weifeng Zhu, Cheng Huang, Qian Miao, Gen Lin, Wu Zhuang, Yun-jian Huang, Xirong Fan, Xiandong Lin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Population H&E stain 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Stage (cooking) Lung cancer education non-small cell lung cancer education.field_of_study business.industry Tumor-infiltrating lymphocytes Cancer medicine.disease Squamous carcinoma 030104 developmental biology programmed death ligand 1 tumor infiltrating lymphocytes 030220 oncology & carcinogenesis prognosis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Gen Lin 1 , Xirong Fan 1 , Weifeng Zhu 2 , Cheng Huang 1 , Wu Zhuang 1 , Haipeng Xu 1 , Xiandong Lin 3 , Dan Hu 2 , Yunjian Huang 1 , Kan Jiang 1 , Qian Miao 1 and Chao Li 2, 4 1 Department of Thoracic Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China 2 Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China 3 Department of Molecular Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, China 4 Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou 350014, China Correspondence to: Chao Li, email: lichao3501@163.com Keywords: non-small cell lung cancer, prognosis, programmed death ligand 1, tumor infiltrating lymphocytes Received: June 20, 2017 Accepted: July 26, 2017 Published: August 12, 2017 ABSTRACT Programmed death ligand 1 (PD-L1) expression is a predictive biomarker of the success of PD-1/PD-L1 inhibitor therapy for patients with advanced non-small cell lung cancer (NSCLC) but its role as a prognostic marker for early stage resectable NSCLC remains unclear. Here, we studied PD-L1 expression and tumor infiltrating lymphocytes (TILs) in surgically resectable NSCLC and correlate the finding with clinicopathological features and patient outcomes. Total of 170 archival samples of resectable NSCLC were probed for PD-L1 expression using the clone 22C3 pharmDx kit. The PD-L1 expression was determined by the Tumor Proportion Score (TPS) and classified into TPS |
| Databáze: | OpenAIRE |
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