Association of genetic polymorphisms at 1q22 but not 10q23 with gastric cancer in a southern Chinese population
| Autor: | Cui-Ping Zhou, Fen-Xia Li, Xue-Xi Yang, Ying-Shong Wu, Ming Li, Ni-ya Hu |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research China Best fitting Esophageal Neoplasms Genotype Epidemiology Population Single-nucleotide polymorphism Locus (genetics) Biology Logistic regression Polymorphism Single Nucleotide Asian People Gene Frequency Stomach Neoplasms Genetic model Biomarkers Tumor Humans Genetic Predisposition to Disease education Genetics education.field_of_study Chromosomes Human Pair 10 Public Health Environmental and Occupational Health Southern chinese Middle Aged Oncology Chromosomes Human Pair 1 Case-Control Studies Female Genome-Wide Association Study |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(6) |
| ISSN: | 2476-762X |
| Popis: | Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophageal squamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22 and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southern Chinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23 are associated with the risk of GC in a southern Chinese population. Methods: We selected seven top significant associated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based case- control study in a southern Chinese population. Genotypes were determined using MassARRAYTM system (Sequenome, San Diego, CA). Results: Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for age and sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT (OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results for the five SNPs at 10q23 were obtained in this study. Conclusion: These outcomes indicate that 1q22 is associated with GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was not confirmed. |
| Databáze: | OpenAIRE |
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