Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice
| Autor: | J. Nicholas P. Rawlins, Amy M. Taylor, David M. Bannerman, David J. Sanderson, Burkhard Niewoehner, Rolf Sprengel, Peter H. Seeburg |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Research Report
Dissociation (neuropsychology) Trace conditioning Short-term memory Non-spatial memory AMPA receptor Mice 03 medical and health sciences Behavioral Neuroscience Spatial memory Discrimination Psychological 0302 clinical medicine Conditioning Psychological Animals 0501 psychology and cognitive sciences Receptors AMPA 050102 behavioral science & comparative psychology Maze Learning AMPA receptors Recognition memory Mice Knockout Memory Disorders Conditional learning 05 social sciences Association Learning Classical conditioning Associative learning Disease Models Animal Memory Short-Term Space Perception Knockout mouse Female Memory consolidation Cues Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research Behavioural brain research, 2011, Vol.224(1), pp.8-14 [Peer Reviewed Journal] |
| Popis: | Highlights ► GluA1 AMPAR subunit is important for short-term recognition memory. ► We tested whether GluA1 is necessary for short-term memory in trace conditioning. ► GluA1 deletion impaired rewarded alternation, but not trace conditioning. ► The dissociation may reflect processing of different short-term memory traces. GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning. |
| Databáze: | OpenAIRE |
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