Dysfunction of Membrane-Receptor System of Blood Cells and Kidney Tissue in Experimental Diabetes Mellitus
| Autor: | A. E. Gurina, A. A. Terent’ev, N. P. Mikaelian |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Erythrocytes Oxidative phosphorylation Biology Kidney medicine.disease_cause Oxidative Phosphorylation Streptozocin General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Membrane Lipids Adenosine Triphosphate Diabetes mellitus Internal medicine medicine Animals Glycolysis Lactic Acid Rats Wistar Cell Membrane General Medicine medicine.disease Streptozotocin Receptor Insulin Rats Oxidative Stress Insulin receptor medicine.anatomical_structure Endocrinology Lactic acidosis biology.protein Acidosis Lactic Lipid Peroxidation Sodium-Potassium-Exchanging ATPase Energy Metabolism Oxidative stress medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 154:610-613 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-013-2011-x |
| Popis: | The effect of streptozotocin-induced diabetes mellitus on some parameters of energy metabolism and functional status of cell membranes was studied in experiments on rats. It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhibition of aerobic ATP synthesis, accumulation of lactate, uncoupling of oxidative phosphorylation, and development of lactic acidosis. Diabetes mellitus leads to restructuring of membrane lipids, changes in microviscosity, and suppression of insulin receptors and membrane-bound Na(+), K(+)-ATPase, and Ca(2+)-ATPase. Sharply increased levels of LPO products and lactic acidosis during DM indicate an imbalance in the LPO-antioxidant system and development of oxidative stress. |
| Databáze: | OpenAIRE |
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