Verruculotoxin, a new mycotoxin from Penicillium verruculosum
| Autor: | Richard J. Cole, Jerry W. Kirksey, G. Morgan-Jones |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemical Phenomena Metabolite Biology Toxicology medicine.disease_cause Mass Spectrometry Microbiology Lethal Dose 50 chemistry.chemical_compound Column chromatography Fungal metabolite Amide medicine Animals Mycotoxin Pharmacology Penicillium verruculosum Toxin Penicillium Mycotoxins Verruculotoxin Chemistry chemistry Biochemistry Spectrophotometry Ultraviolet Chickens |
| Zdroj: | Toxicology and applied pharmacology. 31(3) |
| ISSN: | 0041-008X |
| Popis: | A toxigenic mold identified as Penicillium verruculosum Peyronel was found during screening for toxic fungal isolates from green peanuts. The major toxic metabolite, purified by column chromatography, had an LD50 of about 20 mg/kg when given orally to 1-day-old cockerels. Chemical and physical data on the purified toxin showed a molecular formula of C15H20N2O and strongly suggested that it contained a secondary amide with a monosubstituted aromatic ring not in conjugation with the amide function. Data from this toxin did not correspond to those from any previously reported toxic fungal metabolite; therefore, this toxin may represent a totally new class of mycotoxins. |
| Databáze: | OpenAIRE |
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