Assessment of redox state and biochemical parameters of salivary glands in streptozotocin-induced diabetic male rats treated with mate tea (Ilex paraguariensis)
| Autor: | Marco Aurélio Gomes, Carolina Manzano, Thayane Miranda Alves, Gabriela Alice Fiais, Rayara Nogueira Freitas, Maria Sara de Lima Coutinho Mattera, Rita Cássia Menegati Dornelles, Doris Hissako Matsushita, Ana Cláudia de Melo Stevanato Nakamune, Antonio Hernandes Chaves-Neto |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Glutathione Peroxidase Superoxide Dismutase Cell Biology General Medicine Catalase Glutathione Lipids Thiobarbituric Acid Reactive Substances Antioxidants Salivary Glands Streptozocin Diabetes Mellitus Experimental Rats Uric Acid Otorhinolaryngology Ilex paraguariensis Amylases Animals Powders Rats Wistar General Dentistry Oxidation-Reduction Teas Herbal |
| Zdroj: | Archives of oral biology. 143 |
| ISSN: | 1879-1506 |
| Popis: | The study aimed to assess the effects of mate tea [Ilex paraguariensis] on the redox state and biochemical parameters of salivary glands in diabetic male rats.Twenty-four male Wistar rats (3 months old) were randomly divided into groups (n = 8 per group): control rats that received water (C); diabetic rats that received water (D); diabetic rats treated with mate tea (DMT). The treated streptozotocin-induced diabetic rats were given mate tea powder by intragastric gavage at a dose of 20 mg/kg daily for 28 days. Content of total protein, amylase, oxidative lipid damage, measured as thiobarbituric acid reactive substances (TBARs), oxidative protein damage, measured as protein carbonyl, total antioxidant capacity, uric acid, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were examined by the spectrophotometric method in the parotid and submandibular glands.The D group showed lower total protein, amylase, TBARs, protein carbonyl, total antioxidant capacity, GSH, uric acid, and GPx than the C group in both salivary glands, as well as higher SOD and CAT activities. The DMT group showed higher total protein, amylase, total antioxidant capacity, GSH, uric acid, and GPx than the D group in both salivary glands. Moreover, mate tea increased SOD in the parotid gland and CAT in the submandibular gland of diabetic rats but did not influence TBARs and protein carbonyl in either salivary gland compared to D group.Mate tea increased tissue protein synthesis and improved antioxidant defenses in the salivary glands of streptozotocin-induced diabetic male rats. |
| Databáze: | OpenAIRE |
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