Amyloid load but not regional glucose metabolism predicts conversion to Alzheimer’s dementia in a memory clinic population
| Autor: | Lars Frings, Philipp T. Meyer, Ralph Buchert, Tobias Bormann, Sabine Hellwig, Timo S. Spehl |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Amyloid Population Standardized uptake value 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Fluorodeoxyglucose F18 Humans Medicine Dementia Cognitive Dysfunction Radiology Nuclear Medicine and imaging education Aged Retrospective Studies education.field_of_study business.industry Proportional hazards model Memory clinic Hazard ratio Brain General Medicine Middle Aged medicine.disease Confidence interval Glucose Positron-Emission Tomography Female Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 45:1442-1448 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-018-3983-6 |
| Popis: | The value of imaging regional glucose metabolism with [18F]FDG PET for the prediction of progression from mild cognitive impairment (MCI) to Alzheimer’s dementia (AD) is controversial. The predictive value of imaging with [18F]FDG PET was therefore tested and compared with that of imaging beta-amyloid load with [11C]PIB PET in the same memory clinic population of MCI patients. Thirty-nine patients with MCI who had undergone [18F]FDG as well as [11C]PIB PET were identified from a single-centre clinical registry. [18F]FDG and [11C]PIB PET images were rated as positive or negative for the presence of regional hypometabolism typical of AD and beta-amyloid deposition, respectively. Raters were blinded to the clinical information. Patients were followed clinically for 2.7 ± 1.2 years after PET. Cox proportional hazards models, adjusted for age and sex, were used to test the predictive value of [18F]FDG PET, [11C]PIB PET, and both in combination. [18F]FDG PET did not significantly predict conversion to AD (p > 0.1). By contrast, models including [11C]PIB PET only (p |
| Databáze: | OpenAIRE |
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