Effects of an Active Surveillance Program and Enhanced Infection Control Measures on Carbapenem-Resistant Gram-Negative Bacterial Carriage and Infections in Pediatric Intensive Care
| Autor: | Angeliki Karyoti, Katerina Tsergouli, Emmanuel Roilides, Elias Iosifidis, Maria Sdougka, Athanassios Tsakris, Charalampos Antachopoulos, Eleni Volakli, Theodoros Karampatakis |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Gram-negative bacteria Adolescent medicine.drug_class Immunology Antibiotics Prevalence Intensive Care Units Pediatric Microbiology 03 medical and health sciences Internal medicine Intensive care Epidemiology Drug Resistance Bacterial Gram-Negative Bacteria medicine Infection control Humans Hand Hygiene Prospective Studies Child Watchful Waiting 030304 developmental biology Retrospective Studies Pharmacology Pediatric intensive care unit 0303 health sciences biology 030306 microbiology business.industry Infant Interrupted Time Series Analysis biology.organism_classification Anti-Bacterial Agents Carriage Carbapenems Child Preschool Carrier State Female business Gram-Negative Bacterial Infections |
| Zdroj: | Microbial drug resistance (Larchmont, N.Y.). 25(9) |
| ISSN: | 1931-8448 |
| Popis: | We evaluated the effects of enhanced infection control measures (ICMs) on carriage and infections of carbapenem-resistant Gram-negative bacteria (CRGNB) in a pediatric intensive care unit. We conducted a quasi-experimental study, including patients with infections of CRGNB retrospectively for 13 months and those participating in an active surveillance program prospectively for 22 months. Active surveillance (weekly rectal swabs) was implemented during a 63-week subperiod with standard ICMs and a subsequent 27-week subperiod with enhanced ICMs (intensified ICMs supplemented with audits and feedback). Prevalence, colonization pressure, incidence, and infections of CRGNB and compliance with ICMs and enhanced ICMs were recorded. Evaluation of results was performed using time series (TS) and interrupted TS. Compliance with hand hygiene improved during the second subperiod of active surveillance compared with the first; prevalence, colonization pressure, and incidence of CRGNB decreased significantly. The linear trend of centered moving average for carbapenem-resistant |
| Databáze: | OpenAIRE |
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