Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia
| Autor: | Ingrid P. Dávalos, Esperanza Martínez-Abundis, Luis E. Figuera, Manuel González-Ortiz, J.M. Oliva, V. Machorro, Silvia Esperanza Flores-Martínez, J.P. Mena, J A Tlacuilo-Parra, Mario Salazar-Páramo, José Sánchez-Corona, M.C. Moran, Lucila Sandoval |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Hyperhomocysteinemia medicine.medical_specialty Genotype Population Single-nucleotide polymorphism Polymorphism Single Nucleotide Preeclampsia Gene Frequency Pre-Eclampsia Pregnancy Internal medicine Prevalence medicine Factor V Leiden Humans education Mexico Molecular Biology Allele frequency Methylenetetrahydrofolate Reductase (NADPH2) Genetics Molecular Epidemiology education.field_of_study biology business.industry Factor V Cell Biology Hematology medicine.disease female genital diseases and pregnancy complications Endocrinology Case-Control Studies Methylenetetrahydrofolate reductase biology.protein Molecular Medicine Female business |
| Zdroj: | Blood Cells, Molecules, and Diseases. 35:66-69 |
| ISSN: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2005.03.008 |
| Popis: | The etiology of preeclampsia is still a matter of controversy. An association between hyperhomocysteinemia and preeclamptic patients has been described. A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased plasma homocysteine concentrations. In addition, the polymorphism of gene encoding for Factor V Leiden G1691A is associated with a prothrombotic state in heterozygous subjects. Both mutations in these thrombophilic proteins appear to have different prevalence in the general population and in patients with preeclampsia/eclampsia (PE/E). We studied single nucleotide polymorphisms for MTHFR C677T and coagulation Factor V Leiden in 33 Mexican patients with PE/E as a genetic risk factor for these diseases, comparing with a normotensive pregnant control group. The genotype and allele frequencies of MTHFR C677T and Factor V Leiden mutations between Mexican women with PE/E and healthy controls were not different. We conclude that these polymorphisms do not contribute in the etiology of PE/E as it has been reported in other populations. |
| Databáze: | OpenAIRE |
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