Effect of interleukin-2 on the manifestation and growth of acetoxymethyl-methylnitrosamine-induced colorectal rat adenocarcinoma

Autor: H. Kirchner, M. Salas, F. T. Garzon, Martin R. Berger
Rok vydání: 1986
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 111:79-81
ISSN: 1432-1335
0171-5216
DOI: 10.1007/bf00402782
Popis: The effect of highly purified human interleukin-2 (IL-2) was assessed on acetoxymethyl-methylnitrosamine (AMMN)-induced colorectal Sprague-Dawley rat adenocarcinoma. Treatment was given for 5 weeks and started 5 weeks after a period of 10 weeks intrarectal administration of 2 mg/kg of AMMN once a week. Animals which showed no evidence of tumors by endoscopical examination of the gut were given 10,000 units/kg of IL-2 s.c. into the dorsal region 5 days a week. Blood samples were analyzed from half of the animals before and 72 h after the end of the treatment. The median tumor volume and the median tumor number per rat were lower in the treated group than in the control. A significant decrease in response to two mitogens (PHA, Con-A) was seen in tumor-bearing rats concomitantly with the tumor growth. The immunological suppression was not restored by treatment with IL-2. No differences in natural killer activity or interferon levels were detected between the control and the treated group. These data indicate some antitumor effect of IL-2 given before the manifestation of tumors in AMMN-induced colorectal rat adenocarcinoma.
Databáze: OpenAIRE
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