A PERKy way to make mitochondrial cristae
| Autor: | Barbara Cannon, Jan Nedergaard |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Endocrinology Diabetes and Metabolism Endoplasmic reticulum Regulator 030209 endocrinology & metabolism Mitochondrion Mitochondria Cell biology Mitochondrial Proteins 03 medical and health sciences Norepinephrine 0302 clinical medicine Endocrinology medicine.anatomical_structure Mitochondrial Membranes Brown adipose tissue Mitochondrial cristae medicine Humans Cristae formation medicine.drug |
| Zdroj: | Trends in Endocrinology & Metabolism. 32:417-419 |
| ISSN: | 1043-2760 |
| DOI: | 10.1016/j.tem.2021.04.003 |
| Popis: | PERK protein, that is canonically associated with the response to endoplasmic reticulum stress, may be acquiring a new role as a regulator of the growth of mitochondrial cristae. This role is pertinent not only to the recruitment of brown adipose tissue thermogenic capacity but probably also to directing cristae formation in highly metabolically active organs such as the heart. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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