Effectiveness of Plasmapheresis in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis with Advanced Kidney Dysfunction
| Autor: | Toshiaki Usui, Joichi Usui, Kunihiro Yamagata, Kazuyuki Noguchi, Naoki Morito, Chie Saito, Michio Nagata, Hirayasu Kai, Noriko Uesugi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Anti-Glomerular Basement Membrane Disease medicine.medical_treatment 030232 urology & nephrology Renal function Case Report 030204 cardiovascular system & hematology urologic and male genital diseases anti-glomerular basement membrane antibody glomerulonephritis 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal Medicine medicine Humans Rapidly progressive glomerulonephritis Dialysis Autoantibodies Kidney business.industry urogenital system Glomerulonephritis Plasmapheresis General Medicine Middle Aged Prognosis medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure glomerular crescents dialysis Hemodialysis business Immunosuppressive Agents |
| Zdroj: | Internal Medicine |
| ISSN: | 0918-2918 |
| Popis: | Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis. |
| Databáze: | OpenAIRE |
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