Analysis of Unilateral Adrenal Hyperplasia with Primary Aldosteronism from the Aspect of Messenger Ribonucleic Acid Expression for Steroidogenic Enzymes: A Comparative Study with Adrenal Cortices Adhering to Aldosterone-Producing Adenoma
| Autor: | Kazuhide Shimamatsu, Osamu Nakashima, Yasuyuki Kusaba, Atsushi Iguchi, Junji Irie, Osamu Takahara, Kazuto Shigematsu, Junichiro Shimamatsu, Hideki Sakai, Kioko Kawai |
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| Rok vydání: | 2006 |
| Předmět: |
Adenoma
medicine.medical_specialty 3-Hydroxysteroid Dehydrogenases medicine.drug_class Biology Functional Laterality chemistry.chemical_compound Endocrinology Primary aldosteronism Internal medicine Hyperaldosteronism medicine Cytochrome P-450 CYP11B2 Humans RNA Messenger In Situ Hybridization Hyperplasia Aldosterone medicine.disease Adrenal Cortex Neoplasms Gene Expression Regulation Neoplastic medicine.anatomical_structure chemistry Mineralocorticoid Zona glomerulosa Steroid Hydroxylases Adrenal Cortex Spironolactone Steroid 11-beta-Hydroxylase Steroid 21-Hydroxylase |
| Zdroj: | Endocrinology. 147:999-1006 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/en.2005-0765 |
| Popis: | Unilateral adrenal hyperplasia with primary aldosteronism is very rare and shows similar endocrine features to aldosterone-producing adenoma and bilateral adrenal hyperplasia. In this study, the mRNA expression of steroidogenic enzymes in unilateral adrenal hyperplasia was examined by in situ hybridization. We found subcapsular micronodules composed of spironolactone body-containing cells, which showed intense expression for 3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 18-hydroxylase, and 21-hydroxylase but not 17α-hydroxylase, indicating aldosterone production. This expression pattern was the same as that in unilateral multiple adrenocortical micronodules, reported recently. Additionally, it was noted that a nodule with active aldosterone production was closely adjacent to one showing intense 17α-hydroxylase expression. In the adrenal cortices adhering to aldosterone-producing adenoma, the majority of hyperplastic zona glomerulosa and hyperplastic nodules demonstrated a decreased steroidogenic activity. However, minute nodules indicative of active aldosterone production were found at high frequency. These results suggest that the subcapsular micronodules observed might be the root of aldosterone-producing adenoma. Furthermore, we emphasize the need for long-term follow-up after unilateral adrenalectomy or enucleation of the adenoma because of the possibility that buds with autonomous aldosterone production may still be present in the contralateral or remaining adrenal tissue. |
| Databáze: | OpenAIRE |
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