Cerebrospinal fluid lactate: measurement of an adult reference interval
| Autor: | Victoria Allgar, Ian Holbrook, Sally Slack, Paul Turley |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 030213 general clinical medicine Pathology medicine.medical_specialty Adolescent Clinical Biochemistry Clinical Chemistry Tests Meningitis Bacterial Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Reference Values Viral meningitis medicine Humans Lactic Acid Cerebrospinal fluid lactate measurement Aged Aged 80 and over business.industry 030208 emergency & critical care medicine General Medicine Middle Aged medicine.disease Meningitis Viral Anesthesia Female Bacterial meningitis business |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 53:164-167 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/0004563215591633 |
| Popis: | Background Differentiating bacterial meningitis from viral meningitis is a diagnostic challenge. Cerebrospinal fluid lactate has been proposed as a valuable test to differentiate disease states; however, its use in adults is limited by a lack of robust reference interval data. Methods Cerebrospinal fluid samples with no cells or organisms detected, no culture growth after 48 h, and no increase in cerebrospinal fluid bilirubin were used to derive reference interval data for cerebrospinal fluid lactate in adults ( n = 120). Results A cerebrospinal fluid lactate reference interval of 1.0 (90% CI 0.9–1.1) – 2.2 mmol/L (90% CI 2.0–2.6) was defined. Conclusions Cerebrospinal fluid lactate results are rapidly available to the clinician. When interpreted against the adult reference interval derived in this study, results can help to triage patients presenting with symptoms of meningitis. |
| Databáze: | OpenAIRE |
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