Development of a new model for acute myocardial infarction in rabbits
| Autor: | Zhun Xiao, Xing Guo, Hong Zhou, Zhong-Wei Fan, Bo Xia, Mei-Yun Tan, Yong-Can Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Myocardial Infarction Infarction acute myocardial infarction 030204 cardiovascular system & hematology Anterior Descending Coronary Artery 03 medical and health sciences Electrocardiography 0302 clinical medicine Laboratory Animal Science Internal medicine medicine ST segment Animals Myocardial infarction cardiovascular diseases General Veterinary medicine.diagnostic_test Full Paper business.industry Electrocardiography in myocardial infarction medicine.disease Coronary Vessels left parasternal approach Disease Models Animal 030104 developmental biology medicine.anatomical_structure Parasternal line Cardiology Rabbits obtuse marginal branch business left circumflex coronary artery Blood vessel |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | The rabbit left anterior descending coronary artery is not macroscopically apparent; this often leads to failure in creation of an acute myocardial infarction (AMI) model. In order to devise a simple method with good reproducibility and high success rate for use as a rabbit AMI model, a new surgical technique was developed, in which the obtuse marginal (OM) branch of the left circumflex coronary artery was coagulated with an electric knife using a left parasternal approach. Four weeks after OM branch coagulation, an electrocardiogram (ECG), blood biochemistry analysis, echocardiographic measurements and pathologic analysis were performed. The left parasternal approach provided the surgeon clear visualization of the targeted blood vessel to accurately identify the proper site to occlude. The successful development of AMI was confirmed by ST segment elevation on the ECG, by high levels of AMI-related markers in blood samples, by cardiac functional damage reflected on echocardiographic images and by changes in pathological sections. Furthermore, an acceptable success rate and low mortality were achieved. Hence, this surgical technique was suggested to be a highly reliable and reproducible method to induce AMI in rabbits for the assessment of new therapeutic interventions or regenerative approaches. |
| Databáze: | OpenAIRE |
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