The contribution of behavioral features to caregiver burden in FTLD spectrum disorders

Autor: Adam L. Boxer, Jeannie M Ake, Masood Manoochehri, Ian R. A. Mackenzie, Julie A. Fields, Belen Pascual, Mario F. Mendez, Brian S. Appleby, Neill R. Graff-Radford, Leah K. Forsberg, Katrina L. Devick, Irene Litvan, Nupur Ghoshal, Bradford C. Dickerson, Murray Grossman, Stephanie Cosentino, Jill Goldman, Edward D. Huey, Hilary W. Heuer, Maria I. Lapid, Maria Carmela Tartaglia, Megan S. Barker, Hannah Silverman, Danielle Brushaber, Howard J. Rosen, Chiadi U. Onyike, Bradley F. Boeve, John Kornak
Rok vydání: 2022
Předmět:
Psychosis
Aging
Epidemiology
behavioral symptoms
Apathy
Clinical Trials and Supportive Activities
Clinical Sciences
Psychological intervention
Caregiver Burden
disinhibition
Disease
Neurodegenerative
frontotemporal dementia
Cellular and Molecular Neuroscience
Developmental Neuroscience
Clinical Research
mental disorders
Behavioral and Social Science
medicine
Acquired Cognitive Impairment
Dementia
Humans
Featured Articles
business.industry
Health Policy
neurodegeneration
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Caregiver burden
Frontotemporal lobar degeneration
medicine.disease
Brain Disorders
ALLFTD consortium
Psychiatry and Mental health
Frontotemporal Dementia (FTD)
Mental Health
Caregivers
frontotemporal lobar degeneration
Geriatrics
Frontotemporal Dementia
Neurology (clinical)
Frontotemporal Lobar Degeneration
Geriatrics and Gerontology
medicine.symptom
business
Frontotemporal dementia
Clinical psychology
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 18, iss 9
Alzheimers Dement
Popis: Introduction Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders. Methods In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease. Results Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia. Discussion Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.
Databáze: OpenAIRE
Externí odkaz: