Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin
| Autor: | Miloš Ognjanović, Marija V. Pergal, Vesna Stanković, Branka Petković, Milena Krstić, Ljiljana Babincev, Dalibor M. Stanković |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Mefenamic acid Inorganic chemistry Indomethacin 02 engineering and technology Anti-inflammatory drug analysis 010402 general chemistry 01 natural sciences Materials Chemistry medicine Electrical and Electronic Engineering Boron doped diamond Unmodified BDDE Mechanical Engineering General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Electronic Optical and Magnetic Materials Highly sensitive Electrochemical gas sensor Electrode Differential pulse voltammetry 0210 nano-technology Selectivity medicine.drug |
| Zdroj: | Diamond and Related Materials |
| Popis: | Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutical formulations. © 2020 Elsevier B.V. |
| Databáze: | OpenAIRE |
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