Amniotic fluid fibrinogen degradation products in the prenatal diagnosis of neural tube defects
| Autor: | Angelina C.A. Carvalho, Aubrey Milunsky, Pauline Giannusa, Margaret E. Kimball |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Amniotic fluid Prenatal diagnosis Nervous System Malformations Fibrinogen Nervous System Fibrin Fibrin Fibrinogen Degradation Products Andrology Pregnancy Humans Medicine False Positive Reactions False Negative Reactions Fetus biology business.industry Neural tube nutritional and metabolic diseases Obstetrics and Gynecology Amniotic Fluid nervous system diseases medicine.anatomical_structure Pregnancy Trimester Second Immunology Amniocentesis biology.protein Female alpha-Fetoproteins False positive rate business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 128:294-299 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(77)90624-x |
| Popis: | Elevated levels of fibrin(ogen) degradation products (FDP) have been detected in second-trimester amniotic fluid in association with open neural tube defects (NTD's) in the fetus. The FDP assay has been proposed for the prenatal diagnosis of NTD's and in this paper is compared with the established use of the alpha-fetoprotein (AFP) assay. FDP and AFP levels were measured in 132 amniotic fluid samples, including 20 NTD cases. The false negative and false positive rates for the FDP assay are high compared with the AFP assay, but it may be of value as an adjunct assay to reduce the over-all false positive rate. |
| Databáze: | OpenAIRE |
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