Rapid and Highly Sensitive Detection of Dopamine Using Conjugated Oxaborole-Based Polymer and Glycopolymer Systems
| Autor: | Selvaraj Naicker, Yinan Wang, Thomas Thundat, Garima Thakur, Yohei Kotsuchibashi, Keren Jiang, Ravin Narain |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers Glycopolymer Dopamine Analytical chemistry 02 engineering and technology Biosensing Techniques Conjugated system 010402 general chemistry 01 natural sciences chemistry.chemical_compound Limit of Detection General Materials Science Surface plasmon resonance chemistry.chemical_classification Detection limit Polymer Surface Plasmon Resonance 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences chemistry 0210 nano-technology Selectivity Layer (electronics) Conjugate |
| Zdroj: | ACS applied materialsinterfaces. 9(18) |
| ISSN: | 1944-8252 |
| Popis: | A conjugated polymer interface consisting of an oxaborole containing polymer and a glycopolymer was used for achieving very high selectivity in dopamine (DA) detection. The optimum binding affinity between the polymers promotes the selectivity to DA through a displacement mechanism while remaining unaffected by other structurally related analogs and saccharide derivatives. Real-time detection of DA with very high selectivity and sensitivity has been demonstrated by immobilizing the polymer conjugates on surface plasmon resonance (SPR) and microcantilever (MCL) sensor platforms. Using the conjugated polymer sensing layer, the SPR biosensor was capable of detecting DA in the concentration range of 1 × 10–9 to 1 × 10–4 mol L–1, whereas the MCL sensor showed a limit of detection (LOD) of 5 × 10–11 mol L–1. We find that the sensing mechanism is based on DA-induced reversible swelling of the conjugated polymer layer and this allows regeneration and reuse of the sensor multiple times. Also, we conclude that SPR ... |
| Databáze: | OpenAIRE |
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