A retrospective analysis of nitric oxide inhalation in patients with severe acute lung injury in Sweden and Norway 1991-1994
| Autor: | A. Lindh, Ola Stenqvist, Claes Frostell, C.-J. Wickerts, Hans Stiernström, U. Rudberg, L. Bindslev, C. R. Martling, U. Nathorst-Westfelt, L. A. Johansson, Owe R. Luhr, V. Hornbaek, S. Aardal, Stefan Lundin, L. Berggren |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Time Factors medicine.medical_treatment Lung injury Nitric Oxide Intensive care Administration Inhalation medicine Humans Adverse effect Aged Retrospective Studies Mechanical ventilation Respiratory Distress Syndrome business.industry Respiratory disease Retrospective cohort study General Medicine Middle Aged medicine.disease Pulmonary hypertension Pneumonia Anesthesiology and Pain Medicine Treatment Outcome Anesthesia Female business |
| Zdroj: | Acta anaesthesiologica Scandinavica. 41(10) |
| ISSN: | 0001-5172 |
| Popis: | Background: Patients with severe acute lung injury (ALI) have been treated compassionately on doctors' initiative with inhaled nitric oxide (INO) in Sweden and Norway since 1991. In 1994 the previously used technical grade nitric oxide was replaced by medical grade nitric oxide. Methods: We have carried out a retrospective data collection all identified adult patients treated with IN0 for >4 h during the period 1991-1994 focusing on safety aspects and patient outcome. We used the following exclusion criteria (1) Age 5% were reported during treatment. Conclusion: The overall mortality did not differ dramatically from historical controls with high mortality. Only a randomised study may determine whether IN0 as an adjunct to treatment alters the outcome in severe ALL One cannot at present advocate the routine use of IN0 in patients with ALI outside such studies. |
| Databáze: | OpenAIRE |
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