Microfluidic systems for hydrodynamic trapping of cells and clusters
| Autor: | Celine Macaraniag, Ian Papautsky, Jian Zhou, Qiyue Luan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Fluid Flow and Transfer Processes
Computer science 010401 analytical chemistry Microfluidics Biomedical Engineering Design elements and principles Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics Hydrodynamic trapping 01 natural sciences 0104 chemical sciences Colloid and Surface Chemistry Cell trapping General Materials Science 0210 nano-technology Review Articles |
| Zdroj: | Biomicrofluidics |
| Popis: | Microfluidic devices have been widely applied to trapping and isolation of cells and clusters for controllable intercellular environments and high-throughput analysis, triggering numerous advances in disease diagnosis and single-cell analysis. Passive hydrodynamic cell trapping is one of the simple and effective methods that has been gaining attention in recent years. Our aim here is to review the existing passive microfluidic trapping approaches, including microposts, microfiltration, microwells, and trapping chambers, with emphasis on design principles and performance. We summarize the remarkable advances that hydrodynamic trapping methods offer, as well as the existing challenges and prospects for development. Finally, we hope that an improved understanding of hydrodynamic trapping approaches can lead to sophisticated and useful platforms to advance medical and biological research. |
| Databáze: | OpenAIRE |
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