Analysis and optimal control of an HIV model based on CD4 count

Autor: A. Ishaku, A. M. Gazali, Shuaibu Ahijo Abdullahi, Nafiu Hussaini
Rok vydání: 2019
Předmět:
Zdroj: Journal of mathematical biology. 81(1)
ISSN: 1432-1416
Popis: A non-linear mechanistic model for the transmission dynamics of HIV/AIDS is developed and analyzed. The model classified the infected individuals based on their CD4 count level. Furthermore, education campaign, voluntary testing and counseling and treatment are considered as intervention strategies for controlling the disease. The analysis of the model reveals that imperfect public enlightenment campaign can induce backward bifurcation. It has been shown that when public enlightenment campaign is [Formula: see text] effective, the disease free equilibrium is globally asymptotically stable for [Formula: see text], whereas for [Formula: see text] the global stability of the endemic equilibrium is proved only in a special case. Time dependent controls of the intervention strategies mentioned above are incorporated into the model and the optimal control strategies with minimal implementation cost are identified. In addition, cost effectiveness analysis in the form of incremental cost effectiveness ratio is carried-out to identify the most cost effective strategies. The results suggest that out of the three non dominated strategies, the strategy of educating the newly entrants only or combination of newly entrants and susceptible individuals is very cost effective using per capita GDP of Nigeria as at 2018. However, the choice of which strategy to implement depends on budgetary allocation and resource availability.
Databáze: OpenAIRE
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