High fecundity rates in donor oocyte recipients and in-vitro fertilization surrogates using parenteral oestradiol valerate
| Autor: | L. Vaught, S. Dodge, Rifaat Salem, Michael Feinman, Geoffrey Sher, G. Massaranni, Christo Zouves, J. Andreyko |
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| Rok vydání: | 1993 |
| Předmět: |
Infertility
Adult medicine.medical_specialty medicine.drug_class medicine.medical_treatment Fertilization in Vitro Biology Valerate Endometrium Injections Andrology Human fertilization Pregnancy medicine Humans Surrogate Mothers chemistry.chemical_classification Gynecology In vitro fertilisation Estrogens Conjugated (USP) Estradiol Rehabilitation Obstetrics and Gynecology Middle Aged medicine.disease Oocyte Tissue Donors medicine.anatomical_structure Fertility Reproductive Medicine chemistry Estrogen Oocytes Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human reproduction (Oxford, England). 8(7) |
| ISSN: | 0268-1161 |
| Popis: | Ovum donation and in-vitro fertilization (IVF) surrogacy can help couples with difficult infertility problems achieve pregnancy. Most centres using oral oestrogens and oestradiol patches report pregnancy rates in the range of 30% per cycle. Parenteral oestradiol valerate has pharmacological properties that make it an attractive option for preparing the endometrium in the recipients undergoing these procedures. When the egg providers were under age 35 years, and using oestradiol valerate in the recipients, we achieved a 61% clinical pregnancy rate in 62 cycles. These improved results suggest that parenteral oestradiol valerate should be used to prepare the endometrium in recipients, and that the hormonal milieu of the endometrium plays an important role in the higher implantation rates obtainable in ovum donor and IVF surrogate cycles. |
| Databáze: | OpenAIRE |
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