NSAID enteropathy and bacteria: a complicated relationship

Autor: Stephanie D. Syer, Anne Aucouturier, Michael G. Surette, Giada De Palma, Premek Bercik, Philippe Langella, John L. Wallace, Rory W. Blackler, Elena F. Verdu, Rebeca Martín, Laura Rossi
Přispěvatelé: Department of Medicine, McMaster University [Hamilton, Ontario], MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Department of Physiology and Pharmacology, University of Calgary, Department of Pharmacology and Toxicology, University of Toronto, Crohn's Colitis Canada, Canadian Institutes of Health Research
Jazyk: angličtina
Rok vydání: 2015
Předmět:
[SDV]Life Sciences [q-bio]
Antibiotics
Gastroenterology
law.invention
Pathogenesis
antibiotique
Probiotic
0302 clinical medicine
law
Lactobacillus
antibiotic
Intestine
Small
skin and connective tissue diseases
Enterohepatic circulation
hydrogène sulfuré
Bifidobacterium
0303 health sciences
hydrogensulfides
biology
Hydrogen sulfide
hémorragie
Microbiota
Anti-Inflammatory Agents
Non-Steroidal
probiotique
Anti-Bacterial Agents
3. Good health
Host-Pathogen Interactions
030211 gastroenterology & hepatology
haemorrhage
medicine.symptom
probiotic
medicine.medical_specialty
medicine.drug_class
Inflammation
digestive system
03 medical and health sciences
intestin
Internal medicine
medicine
Humans
intestine
030304 developmental biology
ulcer
Probiotics
Bleeding
ulcere
biology.organism_classification
digestive system diseases
Intestinal Diseases
inflammation
Immunology
Gastric acid
Zdroj: Journal of Gastroenterology
Journal of Gastroenterology, Springer Verlag, 2015, 50 (4), pp.387-393. ⟨10.1007/s00535-014-1032-1⟩
ISSN: 0944-1174
1435-5922
DOI: 10.1007/s00535-014-1032-1⟩
Popis: The clinical significance of small intestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains under-appreciated. It occurs with greater frequency than the damage caused by these drugs in the upper gastrointestinal tract, but is much more difficult to diagnose and treat. Although the pathogenesis of NSAID enteropathy remains incompletely understood, it is clear that bacteria, bile, and the enterohepatic circulation of NSAIDs are all important factors. However, they are also interrelated with one another. Bacterial enzymes can affect the cytotoxicity of bile and are essential for enterohepatic circulation of NSAIDs. Gram-negative bacteria appear to be particularly important in the pathogenesis of NSAID enteropathy, possibly through release of endotoxin. Inhibitors of gastric acid secretion significantly aggravate NSAID enteropathy, and this effect is due to significant changes in the intestinal microbiome. Treatment with antibiotics can, in some circumstances, reduce the severity of NSAID enteropathy, but published results are inconsistent. Specific antibiotic-induced changes in the microbiota have not been causally linked to prevention of intestinal damage. Treatment with probiotics, particularly Bifidobacterium, Lactobacillus, and Faecalibacteriaum prausnitzii, has shown promising effects in animal models. Our studies suggest that these beneficial effects are due to colonization by the bacteria, rather than to products released by the bacteria.
Databáze: OpenAIRE
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