DNA ploidy level as prognostic factor in low stage carcinoma of the uterine cervix
| Autor: | Gert Jan Fleuren, W. Mooy, Gemma G. Kenter, J. Hermans, Heintz Ap, E.J. Aartsen, Cees J. Cornelisse |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Uterine Cervical Neoplasms Gastroenterology Internal medicine Carcinoma Medicine Humans Neoplasm Invasiveness Radical Hysterectomy Stage (cooking) Lymph node Cervix Neoplasm Staging Gynecology Ploidies business.industry Proportional hazards model Obstetrics and Gynecology DNA Neoplasm medicine.disease Prognosis medicine.anatomical_structure Oncology Lymphatic Metastasis Lymphadenectomy Female Lymph Lymph Nodes business |
| Zdroj: | Gynecologic oncology, 39(2), 181-185. Academic Press Inc. |
| ISSN: | 0090-8258 |
| Popis: | Flow cytometry was used to measure DNA content of tumor cells in paraffin-embedded archival material from 89 patients with squamous cell carcinoma of the cervix uteri stages IB and IIA. Patients were all treated with radical hysterectomy and transperitoneal lymphadenectomy. Twenty-four percent received radiotherapy postoperatively because of tumor spread into parametria or positive lymph nodes. Ploidy grade was compared to other prognostic factors. DNA-aneuploidy was seen in 44 (49%), DNA-diploidy in 16 (18%) and 29 (33%) of the tumors were DNA-periploid. Sixty-nine (78%) patients were in FIGO stage IB, 20 (22%) in IIA. In 19 (21%) lymph node metastases were found, vasoinvasion in 25 (28%). Overall disease-specific 5-year survival was 80%. There was a significant effect of positive lymph nodes (90% vs 47%) and vasoinvasion (87% vs 64%) on the 5-year survival (resp. P less than 0.01 and P = 0.02). No correlation was found between stage (81% for IB vs 80% for IIA) or DNA-ploidy grade (81% for aneuploidy, 82% for periploidy, 79% for diploidy) and survival (resp. P = 0.9 and P = 0.8). Ploidy grade was equally divided over other prognostic factors. In stepwise Cox regression analysis DNA-ploidy grade showed no independent effect on survival. We conclude that DNA flow cytometry in this material was of no additional prognostic value. |
| Databáze: | OpenAIRE |
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