Metabolic aspects of methylcyclopentadienyl manganese tricarbonyl in rats
| Autor: | W. Crocker, Joan Adams, J.F. Stara, L.L. Hall, W. Moore |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urinary Bladder Administration Oral Urine Kidney Whole-Body Counting Biochemistry Excretion Feces chemistry.chemical_compound Biotransformation Internal medicine Abdomen mental disorders Organometallic Compounds medicine Animals Dosing Lung Pancreas General Environmental Science Radioisotopes Manganese Methylcyclopentadienyl manganese tricarbonyl Environmental Exposure Metabolism Rats Spectrometry Gamma Endocrinology medicine.anatomical_structure Adipose Tissue Liver chemistry Injections Intravenous |
| Zdroj: | Environmental Research. 8:171-177 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(74)90049-8 |
| Popis: | Whole-body retention, excretion, and tissue distribution of 54Mn were studied in rats following oral and intravenous dosing of methylcyclopentadienyl 54manganese tricarbonyl (MMT). An initial rapid excretion of most of the 54Mn occurred following both routes of exposure. Extraction of the urine and feces after dosing indicated that the MMT was metabolized and that the 54Mn was excreted in the inorganic form. The high levels of 54Mn found in the urine after MMT dosing are not typical of normal Mn excretion. The liver, kidneys, and lungs contained the highest concentrations of 54Mn following administration of MMT. In vitro experiments indicated that MMT was metabolized in the liver, lung, kidney, and to a small extent in the brain. Metabolism of MMT by kidney homogenate supported the hypothesis that biotransformation occurred in the kidney and explains the high levels of urinary excretion of inorganic 54Mn. The whole body retention curves for 54Mn labeled MMT and 54Mn Cl2 were very similar and are consistent with the hypothesis that MMT is rapidly metabolized. Both curves for 54Mn reflect the kinetics of inorganic Mn. |
| Databáze: | OpenAIRE |
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