Sensory manifestations in Charcot-Marie-Tooth disease
| Autor: | Franco Gemignani, S Alfieri, Adriana Marbini, Giorgia Melli, C Inglese |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pain Sensory system Disease Sensory Manifestations Tooth disease Sural Nerve Charcot-Marie-Tooth Disease Internal medicine Humans Medicine Prospective Studies Age of Onset Prospective cohort study Aged Aged 80 and over business.industry General Neuroscience Middle Aged Surgery Electrophysiology Nociception Sensation Disorders Neuropathic pain Cohort Female Neurology (clinical) business |
| Zdroj: | Journal of the Peripheral Nervous System. 9:7-14 |
| ISSN: | 1529-8027 1085-9489 |
| Popis: | Involvement of sensory nerves in Charcot-Marie-Tooth (CMT) disease is well known, however, sensory symptoms are usually overlooked. To assess the frequency and features of sensory symptoms in a cohort of patients with CMT, we investigated in a prospective study 52 consecutive CMT patients, diagnosed on the basis of clinical, neuro- physiological, and genetic features and classified in CMT type 1 (CMT1) (20 patients, including 14 with CMT1A) and CMT type 2 (CMT2) (32 patients). Positive sensory symp- toms were reported by 28 patients (54%), including neuropathic pain in 6 patients. Pain, either neuropathic or nociceptive, was present in 29 patients (56%) and in 15 patients as a main symptom. Positive sensory symptoms were present in 24 of 32 CMT2 patients (75%) and in 4 of 20 CMT1 patients (20%) (p |
| Databáze: | OpenAIRE |
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