High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women
| Autor: | Guri Grimnes, Margareta Verelst, Johanna Oberg, Kevin D. Cashman, Rolf Jorde |
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| Rok vydání: | 2016 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry 030232 urology & nephrology Urology Placebo Biochemistry law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Randomized controlled trial Lower Urinary Tract Symptoms law Lower urinary tract symptoms medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Molecular Biology Aged Gynecology Bone mineral Postmenopausal women Dose-Response Relationship Drug business.industry Urine incontinence Cell Biology Vitamins Middle Aged medicine.disease Placebo Effect Postmenopause chemistry Dietary Supplements Molecular Medicine Female business |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 173 |
| ISSN: | 1879-1220 |
| Popis: | Lower urinary tract symptoms (LUTS) are common in postmenopausal women, and have been reported inversely associated with vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) levels. The aim of this study was to investigate if high dose vitamin D supplementation would affect LUTS in comparison to standard dose. In a randomized controlled study including 297 postmenopausal women with low bone mineral density, the participants were allocated to receive capsules of 20 000IU of vitamin D3 twice a week (high dose group) or similar looking placebo (standard dose group). In addition, all the participants received 1g of calcium and 800IU of vitamin D daily. A validated questionnaire regarding LUTS was filled in at baseline and after 12 months. At baseline, 76 women in the high dose group and 82 in the standard dose group reported any LUTS. Levels of serum 25(OH)D increased significantly more in the high dose group (from 64.7 to 164.1nmol/l compared to from 64.1 to 81.8nmol/l, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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