Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats
| Autor: | Vijaya Padma Viswanadha, Kuan Ho Lin, You Liang Hsieh, Ya Fang Chen, Wei Wen Kuo, Chih Yang Huang, Marthandam Asokan Shibu, Ray Jade Chen, Rajendran Peramaiyan, Chia Yao Shen |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cardiac function curve Antioxidant Heart malformation medicine.medical_treatment 3 3′ 4′ 7-Tetrahydroxyflavone Medicine (miscellaneous) Pharmacology Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology In vivo medicine TX341-641 Cardiac remodeling 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply business.industry Therapeutic effect 04 agricultural and veterinary sciences Fisetin 040401 food science Blot chemistry Hypertension Flavonoid cardiovascular system business Food Science |
| Zdroj: | Journal of Functional Foods, Vol 52, Iss, Pp 212-218 (2019) |
| ISSN: | 1756-4646 |
| Popis: | Fisetin, a naturally occurring flavonoid in fruits, nuts and vegetables possess antioxidant and anti-inflammatory properties. This study shows that fisetin exerts preventive and therapeutic effects on hypertension associated cardiac abnormalities in H9c2 cells and Spontaneously Hypertensive Rats (SHRs). For In vitro analysis, H9c2 cells were challenged with AngII and Fisetin (50 µM/mL) was administered either before 2 h or after 12 h of AngII challenge. For In vivo studies, SHRs received oral fisetin (10 mg/kg, twice a week for 6 weeks) and their cardiac function was analyzed by echocardiography. Histological studies and Western blotting were performed to assess the severity and the mechanism of the underlying cardiac abnormality. Fisetin effectively suppressed calcineurin-NFATC3 involved cellular hypertrophic effects as observed in H9c2 cells and in SHR hearts. Fisetin also enhanced cardiac function and restored cardiac morphology and therefore, fisetin is a potential agent against hypertension associated hypertrophy and cardiac deterioration. |
| Databáze: | OpenAIRE |
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