First Recurrence Analysis of 840 Cutaneous Melanomas: A Proposal for a Follow-Up Schedule
| Autor: | Paola Brandani, Umberto Maria Reali, L. Martini, C. Chiarugi |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Skin Neoplasms Time Factors 030218 nuclear medicine & medical imaging 03 medical and health sciences Sex Factors 0302 clinical medicine medicine Humans Statistical analysis Melanoma First Recurrence Histological type business.industry General Medicine Middle Aged medicine.disease Trunk Stage I cutaneous melanoma Plastic surgery Oncology Depth of invasion 030220 oncology & carcinogenesis Female Radiology Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Tumori Journal. 80:188-197 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089169408000305 |
| Popis: | Aims and background A correct follow-up schedule for patients who underwent an excision for stage I cutaneous melanoma might allow the early detection of local and distant metastases. At present, there is no general agreement on follow-up protocols. In order to work out a follow-up guide, we have retrospectively evaluated the records of 840 stage I cutaneous melanoma patients surgically treated and followed during the postoperative period in the Division of Plastic Surgery of the University of Florence from 1975 to 1992. Methods We evaluated the patients’ records by analyzing time, pathway and site of any first recurrence in relation to the main prognostic factors such as patient sex, site, histological type and depth of invasion of each primary melanoma. A statistical analysis was performed. Results To summarize, the salient results were the following: 80% of relapses occurred in the first 3 years and they occurred significantly earlier when the primary melanoma was localized in the trunk and significantly later when the melanoma was localized in the lower limbs and for < 1.5 mm lesions. The first recurrence occurred earlier by the lymphatic than by the hematic pathway regarding the overall number of patients. The hematic pathway was the most frequent (with respect to the overall percentage of hematic metastases) for the melanomas localized in the head and neck region and for lentigo malignant melanomas, whereas the lymphatic pathway was most frequent for melanomas of the lower limbs and > 3 mm in thickness. Conclusions We suggest a follow-up schedule taking into consideration the postoperative behavior of stage I cutaneous melanoma patients (in terms of time and pathway of the first recurrence) in relation to the site and depth of invasion of the tumor. |
| Databáze: | OpenAIRE |
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