Survival after cancer in Italian persons with AIDS, 1986-2005: A population-based estimation
| Autor: | Maso, Ld, Suligoi, B, Franceschi, S, Braga, C, Buzzoni, C, Polesel, J, Zucchetto, A, Piselli, P, Falcini, F, Caldarella, A, Zanetti, R, Vercelli, M, Guzzinati, S, Russo, A, Tagliabue, G, Iachetta, F, Ferretti, Stefano, Limina, Rm, Mangone, L, Michiara, M, Stracci, F, Pirino, Dr, Piffer, S, Giacomin, A, Vitarelli, S, Mazzoleni, G, Iannelli, A, Contrino, Ml, Fusco, M, Tumino, R, Fanetti, Ac, De Paoli, P, Decarli, A, Serraino, D, Cancer, AIDS Registries Linkage Study32 |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Population Aggressive lymphoma survival Young Adult hazard ratio Neoplasms Internal medicine Humans Medicine cancer Pharmacology (medical) Registries cancer survival education Sarcoma Kaposi Aged Lymphoma AIDS-Related AIDS patients Aged 80 and over Cervical cancer Acquired Immunodeficiency Syndrome education.field_of_study Cancer prevention business.industry Lymphoma Non-Hodgkin Hazard ratio Cancer Middle Aged medicine.disease AIDS Survival Analysis Lymphoma Infectious Diseases Italy Female Skin cancer business |
| Zdroj: | BASE-Bielefeld Academic Search Engine ResearcherID |
| Popis: | BACKGROUND Cancer survival in persons with AIDS (PWA) after introduction of antiretroviral therapies remains poorly characterized. The aim is to provide population-based estimates of cancer survival, overall and for the most important cancer types in PWA, and a comparison with persons without AIDS (non-PWA) affected by the same cancer. METHODS PWA with cancer at AIDS diagnosis or thereafter were individually matched with non-PWA by type of cancer, sex, age, year of diagnosis, area of living, and, for lymphomas, histological subtype. Five-year observed survival and hazard ratios (HRs) of death in PWA versus non-PWA with 95% confidence intervals (CIs) were estimated. RESULTS We included 2262 Italian PWA and 4602 non-PWA with cancer diagnosed during 1986-2005. Between 1986 and 1995, and 1996 and 2005, 5-year survival for all cancers in PWA improved from 12% to 41% and the corresponding HR versus non-PWA decreased from 5.1 (95% CI: 4.3 to 6.1) to 2.9 (95% CI: 2.6 to 3.3). During 1996-2005, HRs were 2.0 (95% CI: 1.4 to 2.9) for Kaposi sarcoma, 3.4 (95% CI: 2.9 to 4.1) for non-Hodgkin lymphoma, and 2.4 (95% CI: 1.4 to 4.0) for cervical cancer. HRs were 2.5 (95% CI: 2.1 to 3.1) for all non-AIDS-defining cancers, 5.9 (95% CI: 3.1 to 11.2) for Hodgkin lymphoma, and 7.3 (95% CI: 2.8 to 19.2) for nonmelanoma skin cancer. A ≤3-fold survival difference was found for cancers of the stomach, liver, anus, lung, brain, and the most aggressive lymphoma subtypes. CONCLUSIONS The persisting, although narrowing, gap in cancer survival between PWA and non-PWA indicates the necessity of enhancing therapeutic approaches, so that PWA can be provided the same chances of survival observed in the general population, and improving cancer prevention and screening. |
| Databáze: | OpenAIRE |
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