Persistently High Serum Substance P Levels and Early Mortality in Patients with Severe Traumatic Brain Injury
| Autor: | Jordi Solé-Violán, Victor García-Marín, Mónica Argueso, Leonardo Lorente, Antonia Pérez-Cejas, Alejandro Jiménez, Agustín F. González-Rivero, María M. Martín, Luís F. Ramos, Juan J. Cáceres |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Traumatic brain injury Neuropeptide Substance P Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Brain Injuries Traumatic Humans Medicine In patient Prospective cohort study Neuroinflammation Aged business.industry High serum Middle Aged medicine.disease chemistry 030220 oncology & carcinogenesis Female Surgery Observational study Neurology (clinical) business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 132:e613-e617 |
| ISSN: | 1878-8750 |
| Popis: | Substance P is a neuropeptide belonging to the tachykinin family and is involved in neuroinflammation. In a previous study by our team, we found higher serum substance P levels on day 1 of traumatic brain injury (TBI) in nonsurviving than in surviving patients. Thus, the objective of this study was to determine whether serum substance P levels during the first week of TBI could predict early mortality.This was a multicenter, observational, and prospective study. We included patients with an isolated severe TBI, defining isolated as9 points in non-cranial aspects of Injury Severity Score and severe as9 points of Glasgow Coma Scale. We determined serum substance P concentrations at days 1, 4, and 8 of TBI. We performed receiver operating characteristic analyses to determine the capacity of serum substance P levels at day 1, 4, and 8 of TBI to predict 30-day mortality.Nonsurviving (n = 34) compared with surviving patients (n = 90) had greater serum substance P levels on day 1 (P0.001), 4 (P0.001), and 8 (P0.001) of TBI. The areas under curve of serum substance P concentrations at days 1, 4, and 8 of TBI to predict 30-day mortality were 76% (P0.001), 87% (P0.001), and 89% (P0.001), respectively.The new finding of our study is that the presence of elevated serum substance P levels during the first week of TBI is associated with increased mortality. |
| Databáze: | OpenAIRE |
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