Predictive efficacy of the 2014 International Society of Urological Pathology Gleason grading system in initially diagnosed metastatic prostate cancer
| Autor: | Hao Zeng, Yaojing Yang, Pengfei Shen, Guangxi Sun, Xingming Zhang, Jing Gong, Jiang-Dong Liu, Haojun Gui, Xueqin Chen, Ni Chen, Jinge Zhao, Kunpeng Shu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology China medicine.medical_specialty Pathology overall survival Urology Bone Neoplasms Kaplan-Meier Estimate castration-resistance prostate cancer-free survival International Society of Urological Pathology grading system metastasis prostate cancer lcsh:RC870-923 Disease-Free Survival Metastasis Prostate cancer Predictive Value of Tests Prostate Internal medicine medicine Humans Neoplasm Metastasis Aged Aged 80 and over Gleason grading system Univariate analysis Receiver operating characteristic Proportional hazards model business.industry Prostatic Neoplasms Bone metastasis General Medicine Middle Aged Prognosis medicine.disease lcsh:Diseases of the genitourinary system. Urology Survival Analysis Prostatic Neoplasms Castration-Resistant Treatment Outcome medicine.anatomical_structure Original Article Neoplasm Grading business |
| Zdroj: | Asian Journal of Andrology, Vol 19, Iss 5, Pp 573-578 (2017) Asian Journal of Andrology |
| ISSN: | 1745-7262 |
| Popis: | We compared the predictive ability of the 2014 and 2005 Gleason grading systems in 568 patients initially diagnosed with metastatic prostate cancer (PCa). Outcomes included the duration of castration-resistant prostate cancer-free survival (CFS) and overall survival (OS). Univariate analyses and log-rank tests were used to identify prognosis indicators and assess univariable differences in CFS and OS in Gleason score (GS) groups. Cox proportional hazards and area under the curves of receiver operator characteristics methods were used to evaluate the predictive efficacy of the 2005 and 2014 ISUP grading systems. Univariate analyses showed that the 2005 and 2014 grading systems were prognosticators for CFS and OS; both systems could distinguish the clinical outcome of patients with GS 6, GS 7, and GS 8-10. Using the 2014 criteria, no statistical differences in patient survival were observed between GS 3 + 4 and GS 4 + 3 or GS 8 and GS 9-10. The predictive ability of the 2014 and 2005 grading systems was comparable for CFS and OS (P = 0.321). However, the 2014 grading system did not exhibit superior predictive efficacy in patients initially diagnosed with PCa and bone metastasis; trials using larger cohorts are required to confirm its predictive value. To the best of our knowledge, ours is the first study to compare the 2005 and 2014 grading systems in initially diagnosed PCa with bone metastasis. At present, we recommend that both systems should be used to predict the prognosis of patients with metastatic PCa. |
| Databáze: | OpenAIRE |
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