Synthesis and electrochemical studies of a new iron tetra-catecholamide complex
| Autor: | L. Bricard, B. Keita, M.E. Brik, A. Gaudemer, N. Cheraïti, L. Nadjo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Siderophore
medicine.drug_class Spermidine Clinical Biochemistry Inorganic chemistry Pharmaceutical Science Carboxamide Electrochemistry Iron Chelating Agents Biochemistry Chemical synthesis Redox Mass Spectrometry chemistry.chemical_compound Enterobactin Catecholamines Drug Discovery medicine Molecular Biology biology Organic Chemistry Metabolism biology.organism_classification chemistry Molecular Medicine Tetra |
| Zdroj: | Bioorganicmedicinal chemistry letters. 9(16) |
| ISSN: | 0960-894X |
| Popis: | A new tetra-catecholamide compound N5,N6-thiodipropanoyl-bis[N1,N10-bis(2,3-dihydroxybenzoyl-spermidi ne)] (H8L) has been synthesised as an iron chelator of Fe (III). Cyclic voltammogram of the iron complex H2LFe run under an argon atmosphere shows a quasi-reversible redox process with E0 = -430 mV vs. SCE in CH3OH/H20 (60/40). This value approaches the range of biological reductants and consequently the complex may mimic the release of iron from enterobactin to the agents which are directly involved in cell metabolism. |
| Databáze: | OpenAIRE |
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