Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens
| Autor: | Dana T. Timek, Jianhui Shi, Haiyan Liu, Fan Lin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Carcinoma Hepatocellular Lung Neoplasms Esophageal Neoplasms Biopsy Fine-Needle Adenocarcinoma Glypican 3 Metastatic carcinoma Diagnosis Differential Glypicans Biopsy Biomarkers Tumor medicine Carcinoma Humans Tissue microarray Arginase medicine.diagnostic_test business.industry Liver Diseases Liver Neoplasms General Medicine medicine.disease Immunohistochemistry digestive system diseases Fine-needle aspiration Liver Hepatocellular carcinoma Carcinoma Squamous Cell Neoplasm Grading business |
| Zdroj: | American Journal of Clinical Pathology. 138:203-210 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/ajcpk1zc9wnhccmu |
| Popis: | Distinction of liver metastases from hepatocellular carcinoma (HCC) may present a diagnostic challenge. Arginase-1 (Arg-1) is a marker for HCC recently described in some literature. Immunohistochemical evaluation of Arg-1, hepatocyte paraffin-1 (HepPar-1), and glypican-3 expression was performed on 1,240 surgical specimens and 62 liver fine-needle aspiration specimens (29 HCCs, 28 metastatic tumors, and 5 benign liver cases). The staining results on tissue microarray sections showed that 2.7% and 3.1% of nonhepatic tumor cases were positive for HepPar-1 and glypican-3, respectively; none was positive for Arg-1. For fine-needle aspiration specimens, 19 HCCs were positive for all 3 markers; 9 were positive for 1 or 2 markers; and only 1 case was negative for all 3 markers. These data demonstrate that Arg-1 is the most specific marker in differentiating a non-HCC from HCC. It is recommended to use 3 markers as a panel in distinguishing HCC from metastatic carcinoma. |
| Databáze: | OpenAIRE |
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