Low serum bilirubin concentration is a predictor of chronic kidney disease
| Autor: | Mai Asano, Takafumi Senmaru, Hitoshi Toda, Hiroshi Okada, Ki-ichiro Tomiyasu, Satoshi Akabame, Muhei Tanaka, Naoto Nakamura, Masahiro Yamazaki, Yohei Oda, Michiaki Fukui, Goji Hasegawa |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Bilirubin Population Down-Regulation Renal function Kidney urologic and male genital diseases Gastroenterology chemistry.chemical_compound Japan Risk Factors Internal medicine medicine Humans Renal Insufficiency Chronic education education.field_of_study Creatinine business.industry Hazard ratio Middle Aged Prognosis medicine.disease Health Surveys Endocrinology chemistry Disease Progression Uric acid Female Cardiology and Cardiovascular Medicine business Biomarkers Dyslipidemia Glomerular Filtration Rate Kidney disease |
| Zdroj: | Atherosclerosis. 234:421-425 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2014.03.015 |
| Popis: | Objective Chronic kidney disease (CKD) is a worldwide public health problem. It is very important to identify the factors that affect CKD. Previous studies have reported that serum bilirubin concentration was positively correlated with renal function in a cross-sectional study. The aim of this study was to investigate the relationship between serum bilirubin concentration and the progression of CKD. Methods A cohort study was performed on a consecutive series of 2784 subjects without CKD, defined as estimated glomerular filtration rate (eGFR) 2 , at baseline. We analyzed the relationship between serum total bilirubin concentration at baseline and new-onset CKD in the general population. Results We followed the subjects for a median period of 7.7 years. There were 1157 females and 1627 males, and 231 females and 370 males developed CKD during this period. Multiple Cox regression analyses revealed that serum total bilirubin concentration (hazard ratio (HR) per 1.0 μmol/L increase 0.97 (95% CI 0.95–0.99), P = 0.0084) in addition to age, gamma-glutamyl transpeptidase (GGT), uric acid (UA), creatinine and medication for hypertension in men and serum total bilirubin concentration (HR per 1.0 μmol/L increase 0.96 (95% CI 0.93–1.00), P = 0.0309) in addition to age, GGT, alanine aminotransferase, UA, creatinine and medication for dyslipidemia in women were independent predictors of new-onset CKD, after adjusting for confounders. Conclusion Our study demonstrated that serum total bilirubin concentration could be a novel risk factor for the progression of CKD, defined as eGFR 2 , in the general population. |
| Databáze: | OpenAIRE |
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