The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach
| Autor: | Nadine Amusant, Emeline Houël, Alice M. S. Rodrigues, Didier Stien, Véronique Eparvier, Guillaume Odonne |
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| Přispěvatelé: | Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), PIERRE FABRE-EDF (EDF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS), Laboratoire Ecologie, évolution, interactions des systèmes amazoniens (LEEISA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), 'Investissements d'avenir' of the French National Agency for Research (Labex CEBA) [ANR-10-LABX-25-01], Stien, Didier, Université des Antilles (UA)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-AgroParisTech-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antifungal Candida parapsilosis medicine.drug_class lcsh:Medicine [CHIM.THER]Chemical Sciences/Medicinal Chemistry Citral Article Terpene 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration 0302 clinical medicine 4-Butyrolactone Candida albicans Eugenol medicine Organic chemistry Metabolomics lcsh:Science Thymol Antifungal agents [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology Multidisciplinary biology lcsh:R biology.organism_classification Eugénol 3. Good health Propriété antifongique 030104 developmental biology chemistry S50 - Santé humaine Maladie infectieuse Huile essentielle lcsh:Q U30 - Méthodes de recherche 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9, pp.8729. ⟨10.1038/s41598-019-45222-y⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports (2045-2322) (Nature Publishing Group), 2019-06, Vol. 9, N. 8729, P. 9p. Scientific Reports (9), . (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-45222-y⟩ |
| Popis: | Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the discovery of potent antifungal agents against human pathologies, we embarked upon developing chemometric approach coupled with statistical design to unravel the origin of the anticandidal potential of a set of 66 essential oils (EOs). EOs were analyzed by GC-MS and tested against Candida albicans and C. parapsilosis (Minimal Inhibitory Concentration, MIC). An Orthogonal Partial Least Square (OPLS) analysis allowed us to identify six molecules presumably responsible for the anticandidal activity of the oils: (Z)-ligustilide, eugenol, eugenyl acetate, citral, thymol, and β-citronellol. These compounds were combined following a full factorial experimental design approach in order to optimize the anticandidal activity and selectivity index (SI = IC50(MRC5 cells)/MIC) through reconstituted mixtures. (Z)-Ligustilide and citral were the most active compounds, while (Z)-ligustilide and eugenol were the two main factors that most contributed to the increase of the SI. These two terpenes can, therefore, be used to construct bioinspired synergistic anticandidal mixtures. |
| Databáze: | OpenAIRE |
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