Multifunctional Nanovehicles for Combined 5-Fluorouracil and Gold Nanoparticles Based on the Nanoprecipitation Method
| Autor: | Mukhles Sowwan, Maryam Faroun, Abeer Karmi, Ghaleb A. Husseini |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Materials science
Scanning electron microscope Electrostatic force microscope Biomedical Engineering Metal Nanoparticles Nanoparticle Bioengineering Microscopy Atomic Force chemistry.chemical_compound Drug Delivery Systems Polylactic Acid-Polyglycolic Acid Copolymer Chemical Precipitation Nanotechnology General Materials Science Lactic Acid Particle Size technology industry and agriculture General Chemistry Photothermal therapy Condensed Matter Physics PLGA Chemical engineering chemistry Transmission electron microscopy Colloidal gold Drug delivery Microscopy Electron Scanning Fluorouracil Gold Porosity Polyglycolic Acid |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 11:4675-4683 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2011.4156 |
| Popis: | To facilitate the administration of combined 5-Fluorouracil (5-FU) and gold nanoparticles (for photothermal treatment purposes), we developed 5-FU-gold-poly(lactide-co-glycolic acid) (5-FU-Au-PLGA) nanovehicles, via the nanoprecipitation method. The gold nanoparticles were incorporated inside the 5-FU-PLGA carriers using a roller mixer. Morphological analysis using atomic force microscopy (AFM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), indicated uniform, singly separated spherical nanoparticles (NPs). Drug content, recovery and entrapment in the NPs were approximated using UV-spectrophotometer data. Approximately 26% of nanoparticles were recovered after drying. The percentage of total drug content was about 30%, and the percentage of drug entrapment reached 57%. Electrostatic Force Microscopy images confirmed the presence of gold inside the drug-loaded nanoparticles. We speculate that the 20-nm gold particles were able to diffuse, after 12 hours of mixing (using the roller mixer), into the PLGA matrix through the 100-nm pores (observed by SEM) without affecting the integrity of the drug delivery vehicle. These synthesized nanoparticles show promise as multimodal vehicles in the delivery of chemotherapeutic agents. |
| Databáze: | OpenAIRE |
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