Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese
| Autor: | Damien Mandry, Faiez Zannad, Pierre-Yves Marie, Paolo Salvi, Gilles Karcher, Laure Joly, Anna Kearney-Schwartz, Christine Perret-Guillaume, Patrick Rossignol, Athanase Benetos |
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| Přispěvatelé: | Service de médecine gériatrique, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Radiologie [CHRU Nancy], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Médecine Nucléaire [Nancy], Felblinger, Jacques |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
MESH: Abdominal Wall MESH: Vascular Resistance Pulsatile flow MESH: Aorta Abdominal Contrast Media 030204 cardiovascular system & hematology Phase contrast magnetic resonance imaging law.invention Body Mass Index MESH: Magnetic Resonance Imaging 0302 clinical medicine law MESH: Obesity Statistical analysis 030212 general & internal medicine Aorta Abdominal Prospective Studies Pulse wave velocity [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM] 2. Zero hunger MESH: Statistics Nonparametric [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] MESH: Middle Aged medicine.diagnostic_test Nutritional status MESH: Blood Flow Velocity Middle Aged Magnetic Resonance Imaging [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Pulsatile Flow MESH: Waist Circumference MESH: Pulsatile Flow cardiovascular system Female Radiology Waist Circumference Blood Flow Velocity circulatory and respiratory physiology medicine.medical_specialty MESH: Hemodynamics MESH: Probability Phase contrast microscopy Statistics Nonparametric MESH: Body Mass Index 03 medical and health sciences MESH: Analysis of Variance MESH: Contrast Media Internal Medicine medicine Humans Obesity cardiovascular diseases Probability Analysis of Variance MESH: Humans business.industry Abdominal Wall Hemodynamics Magnetic resonance imaging medicine.disease Elasticity MESH: Male MESH: Prospective Studies Arterial stiffness MESH: Elasticity Vascular Resistance [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] business MESH: Female Biomedical engineering |
| Zdroj: | Hypertension Hypertension, American Heart Association, 2009, 54 (2), pp.421-6. ⟨10.1161/HYPERTENSIONAHA.109.133645⟩ |
| ISSN: | 0194-911X 1524-4563 |
| DOI: | 10.1161/HYPERTENSIONAHA.109.133645⟩ |
| Popis: | Carotid-femoral pulse wave velocity (PWV) is considered the gold-standard measurement of arterial stiffness. Obesity, however, can render inaccurate the measurement of PWV by external noninvasive devices. Phase-contrast MRI allows the determination of aortic PWV in multiple aortic locations with intra-arterial distance measurements, as well as the assessment of aortic mechanical properties. The purpose of this study was to assess the reliability of external carotid-femoral PWV values measured by well-validated external devices in comparison with MRI acquisitions of PWV and aortic mechanical properties in a population of obese subjects. PWV was measured with PulsePen and Complior II devices in 32 volunteers (18 men and 14 women), aged 46 to 65 years (mean: 55.7±5.1 years), presenting with isolated abdominal obesity, with a waist circumference >102 cm for men and >88 cm for women, and a body mass index between 27 and 35. These results were then compared with MRI PWV values and cross-sectional MRI thoracic aorta distensibility values. MRI PWV values were positively correlated with PWV measured by both PulsePen ( r =0.47; P =0.005) and Complior ( r =0.43; P =0.01). Aortic cross-sectional stiffness was positively correlated with PulsePen PWV ( r =0.42; P =0.02). The same trend was also observed with Complior PWV ( r =0.33; P =0.06). This is the first study comparing transcutaneous PWV measurements with MRI aortic elastic properties in obese subjects. Our results indicate that, for body mass index values ≤35 kg m −2 , PWV measured externally with Complior or PulsePen validly reflect values obtained directly in the thoracic aorta through MRI. |
| Databáze: | OpenAIRE |
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