Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays
| Autor: | Barbora Jarošová, Peter A. Bain, Jordan Crago, Fujio Shiraishi, Frederic D.L. Leusch, Keith A. Maruya, Wibke Busch, Guanyong Su, Andrew R. Humpage, Ai Jia, Xiaowei Zhang, Janet Y. M. Tang, Bart van der Burg, Anu Kumar, Mayumi Allinson, Elke Dopp, Shane A. Snyder, Nancy D. Denslow, Inge Werner, Alexander V. Medvedev, Alvine C. Mehinto, Min Yang, Erik Prochazka, Daniel Schlenk, Marina Grimaldi, Patrick Balaguer, Stefan Scholz, Andrea Schifferli, Bonnie H. Y. Yeung, Sergei S. Makarov, Chris K C Wong, Rolf Altenburger, B. Sumith Jayasinghe, Beate I. Escher, Jamie E. Mendez, Jessica Richard, Sandy D. Westerheide, Sander C. van der Linden, Anita H. Poulsen, Klára Hilscherová |
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| Přispěvatelé: | Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Předmět: |
[SDV.CAN]Life Sciences [q-bio]/Cancer
Portable water purification Biological Assay Chemical/*analysis Wastewater In Vitro Techniques Water Purification Water Quality Charcoal/analysis Toxicity Tests Animals Environmental Chemistry Bioassay Recycling Water Pollutants Effluent Zebrafish Chemistry Drinking Water Australia Water Estrogens Estrogens/analysis Water Quality/*standards General Chemistry 6. Clean water Benchmarking Drinking Water/*analysis/standards 13. Climate action Charcoal Environmental chemistry Ultrapure water Water/analysis Water treatment Waste Water/*analysis Water quality Surface water Water Pollutants Chemical Filtration |
| Zdroj: | ResearcherID Environmental Science and Technology Environmental Science and Technology, American Chemical Society, 2014, 48, pp.1940--56. ⟨10.1021/es403899t⟩ |
| ISSN: | 0013-936X 1520-5851 |
| Popis: | Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective of this study was to evaluate cell-based bioassays for their suitability to benchmark water quality and to assess efficacy of water treatment processes. The selected bioassays cover relevant steps in the toxicity pathways including induction of xenobiotic metabolism, specific and reactive modes of toxic action, activation of adaptive stress response pathways and system responses. Twenty laboratories applied 103 unique in vitro bioassays to a common set of 10 water samples collected in Australia, including wastewater treatment plant effluent, two types of recycled water (reverse osmosis and ozonation/activated carbon filtration), stormwater, surface water, and drinking water. Sixty-five bioassays (63%) showed positive results in at least one sample, typically in wastewater treatment plant effluent, and only five (5%) were positive in the control (ultrapure water). Each water type had a characteristic bioanalytical profile with particular groups of toxicity pathways either consistently responsive or not responsive across test systems. The most responsive health-relevant endpoints were related to xenobiotic metabolism (pregnane X and aryl hydrocarbon receptors), hormone-mediated modes of action (mainly related to the estrogen, glucocorticoid, and antiandrogen activities), reactive modes of action (genotoxicity) and adaptive stress response pathway (oxidative stress response). This study has demonstrated that selected cell-based bioassays are suitable to benchmark water quality and it is recommended to use a purpose-tailored panel of bioassays for routine monitoring. |
| Databáze: | OpenAIRE |
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