Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly
| Autor: | Vivien Gattas, Petra Klassen, Gladys Barrera, Ferdinand Haschke, Daniel Bunout, Maritza Avendaño, Sandra Hirsch, Carlos Muñoz, M Petermann, M P de la Maza, Philippe Steenhout, C Hager |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Aging medicine.medical_treatment Medicine (miscellaneous) Natural killer cell Pneumococcal Vaccines Immune system Antigen Humans Medicine Vitamin B12 Chile Aged Food Formulated Nutrition and Dietetics biology business.industry Vitamin E Lymphokine Immunity Innate Lymphocyte Subsets Killer Cells Natural Vaccination medicine.anatomical_structure Influenza Vaccines Antibody Formation Dietary Supplements Immunology Leukocytes Mononuclear biology.protein Cytokines Female Antibody business Follow-Up Studies |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 28:348-354 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/0148607104028005348 |
| Popis: | Immune response is impaired in the elderly. Our aim was to study the effects of a special nutritional formula on the immune response and response to influenza and pneumococcal vaccination in elderly subjects.Sixty healthy subjects agedor = 70 years, with a Mini Mental scoreor = 22 were studied. Half of the subjects received a special nutritional formula (in addition to the regular diet) providing, among other nutrients, 480 kcal, 31 g proteins, 120 IU vitamin E, 3.8 microg vitamin B12, 400 microg folic acid, 10(9) cfu Lactobacillus paracasei (NCC 2461), and 6 g of fructo-oligosaccharides. At 4 months of follow-up, subjects were vaccinated against influenza and pneumococcus. Lymphokine production by mononuclear cells (PBMC), lymphocyte subpopulations, and natural killer cell (NK) activity were measured at baseline and 4 months of follow-up (before vaccination). Antibodies against influenza and pneumococcal antigens and flu-stimulated production of interferon gamma and interleukin-2 by PBMC were measured at 4 and 6 months. Skin response to 7 recall antigens and body composition were assessed at baseline and at 4 and 12 months. All infections occurring during the study period were recorded.NK activity increased in supplemented subjects and decreased in nonsupplemented individuals. Interleukin-2 production by PBMC and the proportion of T cells with NK activity decreased in controls and did not change in supplemented subjects. Supplemented subjects reported less infections than nonsupplemented individuals (in 13% and 22% of scheduled visits, respectively; p = .02).This nutritional supplement increased innate immunity and protection against infections in elderly people. |
| Databáze: | OpenAIRE |
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