Bullous SLE: response to methotrexate and relationship with disease activity
| Autor: | M G Danieli, G Brandozzi, M Zampetti, M Giangiacomi, G Malcangi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Administration Oral 030204 cardiovascular system & hematology Disease activity 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases 030203 arthritis & rheumatology integumentary system Skin Diseases Vesiculobullous business.industry Dermatology Lupus Nephritis Methotrexate Immunology Female Dermatologic Agents business medicine.drug |
| Zdroj: | Lupus. 12(1) |
| ISSN: | 0961-2033 |
| Popis: | We report on a case of 40-year-old female with systemic lupus erythematosus (SLE) who developed a severe bullous eruption on sun-exposed areas. The bullous manifestation was associated with a flare of lupus serologies, whereas the previous manifestations of the disease were quiescent. Due to prior intolerance to many drugs, she was given oral methotrexate (10 mg=week). The drug administration was followed by a rapid and full resolution of cutaneous lesions. Five months later she developed a class III lupus nephritis. Our case is the first report of efficacy of methotrexate in bullous SLE and rises the question of the relationship between bullous eruption and SLE activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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