Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
| Autor: | V. C. Broudy, J. Humes, K. H. Sprugel, N Lin, M. C. Bailey, T. Papayannopoulou, A. Grossmann, J. W. Forstrom, Kenneth Kaushansky, Hong Ping Ren |
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| Rok vydání: | 1995 |
| Předmět: |
Erythrocytes
Time Factors medicine.medical_treatment Bone Marrow Cells Biology Carboplatin Colony-Forming Units Assay Mice Bone Marrow hemic and lymphatic diseases Proto-Oncogene Proteins Proto-Oncogenes medicine Animals Erythropoiesis Receptors Cytokine Receptors Immunologic Receptor Thrombopoietin Cells Cultured Mice Inbred BALB C Red Cell General Medicine medicine.disease Hematopoietic Stem Cells Recombinant Proteins Cell biology Neoplasm Proteins Leukemia Cytokine medicine.anatomical_structure Erythropoietin Immunology Female Bone marrow Receptors Thrombopoietin Spleen Whole-Body Irradiation medicine.drug Research Article |
| Zdroj: | The Journal of clinical investigation. 96(3) |
| ISSN: | 0021-9738 |
| Popis: | Thrombopoietin (TPO), the ligand for the receptor protooncogene c-mpl, has been cloned and shown to be the critical regulator of platelet production. Several features of c-Mpl expression, including its presence on erythroid cell lines, and the panmyeloid transformation characteristic of myeloproliferative leukemia (MPL) viral disease led us to investigate whether this receptor-ligand system may play a role in erythropoiesis. We report that although TPO alone did not support the growth of either early or late erythroid progenitors, it acted in synergy with erythropoietin to expand these populations. Moreover, while the effects on erythropoiesis in normal animals were modest, TPO greatly expanded the number of erythroid progenitors and blood reticulocytes and was associated with accelerated red cell recovery in myelosuppressed mice. Together, these data strongly suggest that erythroid progenitors respond to TOP and that this newly cloned cytokine, critical for platelet production, can augment erythropoiesis in states of marrow failure. |
| Databáze: | OpenAIRE |
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