GRANULOCYTE COLONY-STIMULATING FACTOR AND NEUTROPHIL RECOVERY AFTER HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE MARROW TRANSPLANTATION
| Autor: | LM Souza, William P. Sheridan, Anthony J. Dodds, J E Layton, Richard M. Fox, Darryl W. Maher, J Lusk, Max Wolf, George Morstyn, Michael D. Green |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Neutropenia Time Factors Cyclophosphamide Granulocyte Gastroenterology Drug Administration Schedule Leukocyte Count Colony-Stimulating Factors Internal medicine Granulocyte Colony-Stimulating Factor medicine Humans Infusions Parenteral Busulfan Infusion Pumps Bone Marrow Transplantation Clinical Trials as Topic medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin Bone Marrow Examination General Medicine Neoplasms Germ Cell and Embryonal medicine.disease Combined Modality Therapy Hodgkin Disease Recombinant Proteins Surgery Granulocyte colony-stimulating factor Bone marrow examination medicine.anatomical_structure Absolute neutrophil count Drug Evaluation Bone marrow business Agranulocytosis medicine.drug |
| Zdroj: | The Lancet. 334:891-895 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(89)91552-3 |
| Popis: | Granulocyte colony-stimulating factor (G-CSF) was administered by continuous subcutaneous infusion to 15 patients with non-myeloid malignancies treated by high-dose chemotherapy and autologous bone marrow infusion. G-CSF was given at variable dosage based on neutrophil count. Sustained serum levels of G-CSF were achieved. Neutrophil recovery was accelerated in G-CSF treated patients compared with 18 historical controls and exceeded 0.5 x 10(9)/l at a mean of 11 days after marrow infusion compared with 20 days for controls, a significant difference. This reduction led to significantly fewer days of parenteral antibiotic therapy, 11 versus 18 days in controls, and less isolation in reverse-barrier nursing, 10 versus 18 days. |
| Databáze: | OpenAIRE |
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