Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice

Autor: Wen-Huang Peng, Min-Min Lee, Tien-Ning Chang, Yi-Chih Chang, Chao-Ying Lee, Shyh-Shyun Huang, Liao Jung-Chun, Jeng-Shyan Deng, Guan-Jhong Huang
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
ISSN: 1741-427X
DOI: 10.1155/2012/595603
Popis: Scopoletin exists in nature as an anti-oxidant, hepatoprotective, and anti-inflammatory activities reagent. In this study, we have investigated the analgesic effects of the scopoletin using the models of acetic acid-induced writhing response and the formalin test, the anti-inflammatory effects of scopoletin using model ofλ-carrageenan (Carr)-induced paw edema. The treatment of ICR mice with scopoletin inhibited the numbers of writhing response and the formalin-induced pain in the late phase. This study demonstrated that the administration of scopoletin resulted in the reduction of Carr-induced mice edema, and it increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) after Carr injection. We also demonstrated scopoletin significantly attenuated the malondialdehyde (MDA) level in the edema paw after Carr injection. Scopoletin decreased the NO, tumor necrosis factor (TNF-α) and prostaglandin E2 (PGE2) levels on serum after Carr injection. Scopoletin decreased Carr-induced inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in the edema paw. These anti-inflammatory mechanisms of scopoletin might be related to the decrease in the level of MDAviaincreasing the activities of SOD, CAT, and GPx in the edema paw. Also, scopoletin could affect the production of NO, TNF-α, and PGE2, and therefore affect the anti-inflammatory effects.
Databáze: OpenAIRE
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