A Unique Response to Staphylococcal Enterotoxin B by Intrahepatic Lymphocytes and its Relevance to the Induction of Tolerance in the Liver
| Autor: | Ayako Mabuchi, M. Saizawa, M. Takahashi, M. Terabe, S. Matsui, Kozo Yokomuro, Shigeo Tanaka |
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| Rok vydání: | 1997 |
| Předmět: |
Staphylococcus aureus
Liver cytology T-Lymphocytes Lymphocyte Immunology Population chemical and pharmacologic phenomena Enterotoxin Biology Lymphocyte Activation Polymerase Chain Reaction Enterotoxins Mice Immune Tolerance Superantigen medicine Animals Mesentery RNA Messenger IL-2 receptor Receptor education DNA Primers Mice Inbred BALB C education.field_of_study Superantigens Receptors Interleukin-2 hemic and immune systems General Medicine Tolerance induction medicine.anatomical_structure Liver Interleukin-2 Female Lymph Nodes Spleen |
| Zdroj: | Scandinavian Journal of Immunology. 46:230-234 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1046/j.1365-3083.1997.d01-118.x |
| Popis: | It has been reported that the intrahepatic lymphocyte (IHL) population is somewhat differently constituted from lymphocytes in other lymphoid tissues. Staphylococcal enterotoxin B (SEB) is a superantigen which can induce T-cell tolerance in mice. The authors investigated the in vitro and in vivo responses of mouse IHL to SEB. An intravenous injection of SEB did not result in the augmentation of the proliferative response of IHL, while mesenteric and splenic lymphocytes (mLNC and SPC, respectively) had augmented responses. Interleukin-2 (IL-2) mRNA was clearly detected in mLNC and SPC by reverse transcriptase-polymerase chain reaction (RT-PCR) shortly after the administration of SEB, but it was scarcely expressed in IHL. The expression of CD25 (IL-2 receptor) was also augmented in mLNC and SPC in the early period, while it was not changed in IHL. These findings suggested that the time required for tolerance induction is different locally and that the loss of augmentation of IL-2 and IL-2 receptor production by IHL may be relevant to the rapid induction of T-cell tolerance in the liver. |
| Databáze: | OpenAIRE |
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