Vascular Endothelial Growth Factor in Pleural Fluid

Autor: R. Michael Rodriguez, Elizabeth A. Perkett, Gary Bienvenu, Jeffrey T. Rogers, Richard W. Light, D.K.-W. Cheng, Urpo Lappalainen
Rok vydání: 1999
Předmět:
Vascular Endothelial Growth Factor A
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Lung Neoplasms
Pleural effusion
medicine.medical_treatment
Breast Neoplasms
Enzyme-Linked Immunosorbent Assay
Thoracentesis
Endothelial Growth Factors
Critical Care and Intensive Care Medicine
Gastroenterology
Parapneumonic effusion
Pleural disease
chemistry.chemical_compound
Internal medicine
medicine
Humans
Malignant pleural effusion
Coronary Artery Bypass
Heart Failure
Lymphokines
L-Lactate Dehydrogenase
Vascular Endothelial Growth Factors
business.industry
Respiratory disease
Proteins
respiratory system
medicine.disease
Pleural Effusion
Malignant
respiratory tract diseases
Pleural Effusion
Vascular endothelial growth factor
chemistry
Pleurisy
Female
Pulmonary Embolism
Cardiology and Cardiovascular Medicine
business
Zdroj: Chest. 116:760-765
ISSN: 0012-3692
DOI: 10.1378/chest.116.3.760
Popis: The purpose of this study was to analyze the relationship of the pleural fluid vascular endothelial growth factor (VEGF) level with the diagnostic category and with the pleural fluid characteristics in a group of 70 patients.The VEGF levels of consecutive patients undergoing therapeutic thoracentesis were determined with an enzyme-linked immunosorbent assay.University-affiliated tertiary care center.The median level of pleural fluid VEGF in the patients with congestive heart failure (150 pg/mL) was significantly (p0.05) lower than the median level in the patients with coronary artery bypass grafting (357 pg/mL), which in turn was significantly lower (p0.05) than the median levels in the patients with malignancy (1,097 pg/mL). The overlap between groups, however, limits the diagnostic usefulness of pleural fluid VEGF levels. The VEGF level was most closely correlated with the lactate dehydrogenase level (r = 0.42, p0.001) and was also significantly correlated with the total pleural fluid protein level. The median VEGF levels in the pleural fluid of patients with breast cancer were significantly lower (p = 0.017) than in those with lung cancer. The VEGF level was very high (3,294 pg/mL) in the one patient with pulmonary embolism.We conclude that the VEGF levels in pleural fluid differ significantly from one diagnostic category to another with the highest median levels occurring in patients with malignant pleural effusions. We speculate that VEGF may be responsible for the pleural fluid accumulation in at least some situations.
Databáze: OpenAIRE
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