The Association of Maternal Iodine Status in Early Pregnancy with Thyroid Function in the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy Study
| Autor: | Carl-Gustaf Bornehag, Arash Derakhshan, Tim I M Korevaar, Deborah Levie, Barbara A. Demeneix, Maarten A. C. Broeren, Robin P. Peeters, Huan Shu, Ralph A de Poortere |
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| Přispěvatelé: | Child and Adolescent Psychiatry / Psychology, Erasmus MC other, Internal Medicine |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Thyroid Hormones Endocrinology Diabetes and Metabolism Population Mothers Nutritional Status 030209 endocrinology & metabolism Reference range Environment Thyroid Function Tests Thyroid function tests Iodide Peroxidase Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Thyroid peroxidase Pregnancy Reference Values medicine Hypersensitivity Prevalence Humans Longitudinal Studies education Child Autoantibodies Sweden education.field_of_study biology medicine.diagnostic_test Obstetrics business.industry Thyroid Infant Newborn Odds ratio medicine.disease Iodine deficiency Asthma medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Female Thyroid function business Iodine |
| Zdroj: | Thyroid, 29(11), 1660-1668. Mary Ann Liebert Inc. |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | Background: Severe maternal iodine deficiency can impact fetal brain development through effects on maternal and/or fetal thyroid hormone availability. The effects of mild-to-moderate iodine deficiency on thyroid function are less clear. The aim was to investigate the association of maternal urinary iodine concentration corrected for creatinine (UI/Creat) with thyroid function and autoantibodies in a mild-to-moderate iodine-deficient pregnant population. Methods: This study was embedded within the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Clinical reference ranges were determined by the 2.5th and 97.5th population-based percentile cutoffs. The associations of UI/Creat with thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), total T4 (TT4), and total T3 (TT3) were studied using multivariable linear regression in thyroid peroxidase antibody (TPOAb)-negative women. The association of UI/Creat with TPOAb and thyroglobulin antibody (TgAb) positivity was analyzed using multivariable logistic regression. Results: Urinary iodine and thyroid function were measured at a median (95% range) gestational age of 10 (6-14) weeks in 2009 women. The median (95% range) UI/Creat was 85 μg/g (36-386) and the UI/Creat was below 150 μg/g in 80.1% of women. Reference ranges did not differ substantially by UI/Creat. A lower UI/Creat was associated with a lower TSH (p = 0.027), a higher TT4 (p = 0.032), and with a corresponding trend toward slightly higher fT4 (p = 0.081), fT3 (p = 0.079), and TT3 (p = 0.10). UI/Creat was not associated with the fT4/fT3 (p = 0.94) or TT4/TT3 ratios (p = 0.63). Women with a UI/Creat of 150-249 μg/g had the lowest prevalence of TPOAb positivity (6.1%), while women with a UI/Creat of |
| Databáze: | OpenAIRE |
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