Fibrinogen deficiency in a dog - a case report

Autor: Olivier Dossin, Armelle Diquélou, Franck Jolivet, Simon Privat, Catherine Trumel
Přispěvatelé: Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), ProdInra, Archive Ouverte
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Dysfibrinogenemia
Case Report
Fibrinogen
Bleeding disorders
Gastroenterology
0403 veterinary science
0302 clinical medicine
Dog Diseases
Fibrinogen deficiency
Hypofibrinogenemia
Dog
Coagulation Disorder
trouble sanguin
Disseminated intravascular coagulation
lcsh:Veterinary medicine
Antithrombin
04 agricultural and veterinary sciences
General Medicine
Afibrinogenemia
3. Good health
030220 oncology & carcinogenesis
dog
Eyelid Diseases
Veterinary medicine and animal Health
medicine.drug
medicine.medical_specialty
040301 veterinary sciences
03 medical and health sciences
Dogs
Internal medicine
medicine
Animals
hemophilia thrombocytopenic purpura
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
business.industry
[SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
medicine.disease
Surgery
Médecine vétérinaire et santé animal
Cryoprecipitate
chien
lcsh:SF600-1100
fibrinogène
fibrinogen
business
Zdroj: BMC Veterinary Research
BMC Veterinary Research, BioMed Central, 2017, 13 (1), ⟨10.1186/s12917-017-1110-8⟩
BMC Veterinary Research, 2017, 13 (1), ⟨10.1186/s12917-017-1110-8⟩
BMC Veterinary Research, Vol 13, Iss 1, Pp 1-5 (2017)
BMC Veterinary Research 1 (13), . (2017)
ISSN: 1746-6148
DOI: 10.1186/s12917-017-1110-8⟩
Popis: Background Among coagulation disorders, primary fibrinogen deficiency is very rare in dogs. It is divided into hypofibrinogenemia, afibrinogenemia and dysfibrinogenemia. Afibrinogenemia has been described in three dogs. There are, however, no published case reports of primary hypofibrinogenemia in dogs. Case presentation A 1.5 year-old male German Pointer dog was evaluated for a locked-jaw syndrome associated with eye protrusion which appeared after a minor head trauma. Three months before the trauma, a persistent increase in coagulation times was detected by the referring veterinarian after a strong suspicion of snake envenomation. Apart for the primary complaint, physical examination was normal. A complete hemostatic profile revealed a moderately increased prothrombin time, activated partial thromboplastin times and a dramatically decreased fibrinogen concentration (0.34 g/L, reference interval [1.3–4.8 g/L]). Platelet count, plasma D-dimers and antithrombin, were all within the reference intervals and not consistent with a disseminated intravascular coagulation. Other possible causes of hypofibrinogenemia such as chronic hemorrhage and liver failure were excluded by laboratory work-up and imaging studies. Finally, antifibrinogen circulating anticoagulants were excluded using a dilution of citrated plasma from the pooled plasma of healthy dogs. These results supported a diagnosis of congenital fibrinogen deficiency and secondary retrobulbar hematoma and/or cellulitis. The dog’s condition improved rapidly after symptomatic treatment with corticosteroids and antibiotics. At the 1 year follow-up, the dog was clinically normal but a persistent hypofibrinogenemia (≤ 0.8 g/L) remained. Conclusions Various clinical presentations may occur in canine primary hypofibrinogenemia which should be included in the list of coagulation disorders. Diagnosis should include fibrinogen determination by coagulometric and non-coagulometric methods to differentiate from dysfibrinogenemia. There is no specific treatment but care should be taken to prevent bleeding and trauma. Emergency management of bleeding episodes with cryoprecipitate is the treatment of choice.
Databáze: OpenAIRE
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