Phase III randomized trial comparing LDR and HDR brachytherapy in treatment of cervical carcinoma
| Autor: | Chotika Jumpangern, Chonlakiet Khorprasert, Apiradee Srisuthep, Chawalit Lertbutsayanukul, Kanjana Shotelersuk, Damrong Tresukosol, Taywin Chottetanaprasith, Prasert Lertsanguansinchai, Prayuth Rojpornpradit, Chulee Charoonsantikul, Sivalee Suriyapee |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Brachytherapy Urinary Bladder Uterine Cervical Neoplasms law.invention Randomized controlled trial law Intestine Small Cervical carcinoma Humans Medicine Stage iib Radiology Nuclear Medicine and imaging Prospective Studies Treatment Failure External beam radiotherapy Radiation Injuries Prospective cohort study Survival rate Aged Radiation business.industry Rectum Radiotherapy Dosage Middle Aged Iridium Radioisotopes Surgery Survival Rate Clinical trial Oncology Cesium Radioisotopes Female Radiology business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 59:1424-1431 |
| ISSN: | 0360-3016 |
| Popis: | Purpose Intracavitary brachytherapy plays an important role in the treatment of cervical carcinoma. Previous results have shown controversy between the effect of dose rate on tumor control and the occurrence of complications. We performed a prospective randomized clinical trial to compare the clinical outcomes between low-dose-rate (LDR) and high-dose-rate (HDR) intracavitary brachytherapy for treatment of invasive uterine cervical carcinoma. Methods and materials A total of 237 patients with previously untreated invasive carcinoma of the uterine cervix treated at King Chulalongkorn Memorial Hospital were randomized between June 1995 and December 2001. Excluding ineligible, incomplete treatment, and incomplete data patients, 109 and 112 patients were in the LDR and HDR groups, respectively. All patients were treated with external beam radiotherapy and LDR or HDR intracavitary brachytherapy using the Chulalongkorn treatment schedule. Results The median follow-up for the LDR and HDR groups was 40.2 and 37.2 months, respectively. The actuarial 3-year overall and relapse-free survival rate for all patients was 69.6% and 70%, respectively. The 3-year overall survival rate in the LDR and HDR groups was 70.9% and 68.4% ( p = 0.75) and the 3-year pelvic control rate was 89.1% and 86.4% ( p = 0.51), respectively. The 3-year relapse-free survival rate in both groups was 69.9% ( p = 0.35). Most recurrences were distant metastases, especially in Stage IIB and IIIB patients. Grade 3 and 4 complications were found in 2.8% and 7.1% of the LDR and HDR groups ( p = 0.23). Conclusion Comparable outcomes were demonstrated between LDR and HDR intracavitary brachytherapy. Concerning patient convenience, the lower number of medical personel needed, and decreased radiation to health care workers, HDR intracavitary brachytherapy is an alternative to conventional LDR brachytherapy. The high number of distant failure suggests that other modalities such as systemic concurrent or adjuvant chemotherapy might lower this high recurrence, especially in Stage IIB and IIIB. |
| Databáze: | OpenAIRE |
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